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Introduction to 4-Fluorococaine Powder

4-Fluorococaine (4′-Fluorococaine), also known as 4′-fluoro cocaine or para-fluorococaine, is a synthetic tropane derivative and structural analogue of cocaine. It is distinguished by the substitution of a fluorine atom at the 4′ position of the benzoyl ester moiety—a modification that preserves cocaine-like affinity at the dopamine transporter (DAT) while profoundly altering its pharmacological profile at the serotonin transporter (SERT) .

Originally developed in the 1990s as a positron emission tomography (PET) radiotracer to study cocaine binding sites in the brain, 4 Fluorococaine has become a valuable tool compound for neuropharmacological research . Its fluorine-18 labeling offers a longer half-life (109.8 minutes) compared to carbon-11 (20.4 minutes), facilitating multi-step radiochemical syntheses and distribution to imaging centers without on-site cyclotrons .

As a research chemical, 4 Fluorococaine is primarily utilized as a certified reference material for forensic and analytical applications, including transporter binding assays, PET imaging studies, and cocaine metabolism research. At 4mmcchems, we supply premium-grade 4-Fluorococaine Powder to researchers and professionals worldwide, with a focus on fast, discreet shipping across Europe.

Product Specifications

Product Name: 4-Fluorococaine Powder (4′-Fluorococaine)

Synonyms: 4′-Fluorococaine, para-Fluorococaine

CAS Number: 134507-62-3

Molecular Formula: C₁₇H₂₀FNO₄

Molecular Weight: 321.34 g/mol

Purity: ≥ 98% (verified by third-party HPLC/GC-MS testing)

Form: Crystalline powder

Storage: -20°C for long-term stability

Availability: In stock, ready for immediate dispatch

Chemical Properties and Mechanism of Action

4 Fluorococaine acts as a monoamine reuptake inhibitor, primarily targeting the dopamine transporter (DAT) and the serotonin transporter (SERT) . Research indicates that this compound exhibits a pharmacological profile that is distinct from cocaine in several important aspects.

Key Pharmacological Data

• DAT Inhibition: 4 Fluorococaine is equipotent to cocaine as an inhibitor of dopamine reuptake, with an IC₅₀ of approximately 200 nM

• SERT Inhibition: The compound is a significantly more potent serotonin reuptake inhibitor than cocaine, with approximately 100-fold enhancement in SERT affinity (IC₅₀ ≈ 7 nM)

• SERT Selectivity Shift: This altered DAT/SERT ratio enables dissociation of dopaminergic from serotonergic contributions in transporter studies

• Butyrylcholinesterase Interaction: 4-Fluorococaine has been characterized as both a substrate and an inhibitor of plasma butyrylcholinesterase (BChE), the enzyme responsible for cocaine’s rapid hydrolytic metabolism

PET Imaging Applications

4-Fluorococaine has been successfully used as a PET radiotracer when labeled with fluorine-18 ([¹⁸F]4-fluorococaine) . The demonstration that [¹⁸F]4-fluorococaine produces PET images equivalent to [¹¹C]cocaine validates its use for probing cocaine binding sites in brain imaging studies .

Why Choose 4mmcchems?

1. Uncompromising Quality

We source our 4-Fluorococaine Powder from certified manufacturers with strict adherence to Good Manufacturing Practice (GMP) guidelines. Every batch undergoes independent HPLC and GC-MS testing to guarantee purity and potency, meeting the ≥98% purity threshold required for analytical reference materials.

2. Discreet and Secure Packaging

Your privacy is paramount. All orders are shipped in plain, unbranded packaging with no external markings indicating contents. Tamper-evident seals ensure security throughout transit.

3. Worldwide Shipping with European Focus

4mmcchems operates a robust global logistics network. We offer fast, reliable shipping to customers worldwide, with a particular emphasis on European markets:

• European Shipping: We have optimized shipping routes to ensure timely delivery to countries including Germany, France, the United Kingdom, Spain, Italy, the Netherlands, Switzerland, and more. Research compounds are available for scientific research purposes under applicable EU regulations .

• Fast Transit Times: Typical delivery to European destinations ranges from 3 to 7 business days.

• Tracking Provided: Every order comes with a tracking number for real-time shipment monitoring.

4. Competitive Pricing and Bulk Discounts

We offer tiered pricing for bulk orders, making 4mmcchems the cost-effective choice for large-scale research projects. Contact our sales team for custom quotes.

5. Responsive Customer Support

Our knowledgeable team is available to answer queries regarding product specifications, shipping, and order status. We prioritize clear and prompt communication.

Safety and Regulatory Information

4-Fluorococaine is classified as a controlled substance in many jurisdictions due to its structural similarity to cocaine and its psychoactive properties. In the United States, it is subject to scheduling under the Controlled Substances Act due to its status as a cocaine analogue . In Canada, it is included under Schedule I of the Controlled Drugs and Substances Act as a derivative of ecgonine .

Important Considerations for Researchers:

• Controlled Status: 4-Fluorococaine is a nationally controlled substance in many jurisdictions. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.

• Research Use Only: This product is intended for research, forensic, and analytical applications only. Not for human or veterinary use .

• Handling Precautions: Standard laboratory safety protocols should be followed when handling this compound. As a potent synthetic analogue of cocaine, it must be handled with extreme caution to prevent occupational exposure. Appropriate personal protective equipment (PPE) including double nitrile gloves, protective gowns, and respiratory protection is recommended .

Shipping Information: Worldwide Delivery

4mmcchems is committed to making our products accessible globally. We ship to all major regions, including:

• Europe: All EU member states, UK, Switzerland, Norway, and more.

• North America: USA, Canada, Mexico.

• Asia: Japan, South Korea, Singapore, China, India, and others.

• Australia & Oceania

• South America

• Middle East & Africa

Shipping Methods:

• Standard Air Mail (7-21 days, tracking available)

• Express Courier (3-7 days, fully tracked, signature required)

Customs and Duties: Customers are responsible for any customs duties or import taxes applicable in their country. We provide all necessary documentation to facilitate smooth customs clearance, subject to local regulations.

How to Order

1. Browse Our Catalog: Select 4-Fluorococaine Powder and add to cart.

2. Checkout: Fill in your shipping details and choose your preferred payment method.

3. Payment: We accept cryptocurrencies and bank transfers for secure transactions.

4. Confirmation: Receive an order confirmation with tracking details upon dispatch.

Frequently Asked Questions

Q: What is 4-Fluorococaine used for in research?

A: 4-Fluorococaine is used as an analytical reference material for research and forensic applications, including transporter binding assays, PET imaging studies, neuropharmacological investigations, and cocaine metabolism research .

Q: Is 4-Fluorococaine legal to purchase?

A: 4-Fluorococaine is a controlled substance in many countries due to its structural similarity to cocaine. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order .

Q: How should 4-Fluorococaine be stored?

A: Store at -20°C for long-term stability. Protect from light and moisture.

Q: What if my order is seized by customs?

A: While we take every precaution to ensure successful delivery, we cannot guarantee customs clearance in all countries, especially given the controls on this compound. Please refer to our shipping policy for more details.